Peripheral neuropathy stem cell treatment

Ligature nerve constriction of sciatic nerve 3 Improved allodynia improved thermal hyperalgesia Improved mechanical allodynia improved heat hyperalgesia в†‘ GABAergic neurons в†‘ antiinflammatory markers (TGFОІ1 and IL-10) в†‘ SOD1, GPx3 expression maintenance of functional neural cells (NF160 cells, MAP2ab, GAP43, GABA, Tuj+, MBP+) в†“ inflammatory cells (ED1+/Iba1+) HATSCs w/ core shell nanoparticles (superparamagnetic iron oxide core w/ photonic zinc oxide shell) в†‘ neuregulin-1 в†‘ epidermal growth factor receptor в†‘ myelination presence of oligodendrocytes differentiated from transplanted cells Here, we review the literature for experimental strategies of examining stem cells for the repair and treatment of neuropathic pain in various disease models to begin to understand common translatable models, identify successes and limitations, and we speculate on these strategies for future directions.Д®xperimental stem cell strategies for the treatment of neuropathic pain * Authors & YearД®mbryonic stem cellвЂ“derived oligodendrocyte progenitor cells We questioned whether experimental strategies examining repair of the injured nervous system is sine qua non for the long-lasting reduction or resolution of chronic neuropathic pain. They also represent a delivery modality for trophic factors for the injured nerve. Stem cells offer a totipotent cellular source for replacing injured or lost neural cells. Stem cell transplantation is a new approach to repairing damaged nervous systemвЂ“induced neuropathic pain syndromes rather than simply providing palliation. Also, there is no treatment strategy that is effective for pain management while promoting nervous system repair. 18 To date, chronic neuropathic pain is largely considered a heterogeneous pain syndrome that remains with limited efficacious treatment modalities. Electrical stimulation via spinal cord, peripheral nerve, and deep brain targeting has begun to show some early efficacy. Intractable neuropathic pain has gained increasing awareness due to its prevalence and the technological advancements in surgical neuromodulation. Treatments have largely depended on anticonvulsants and antidepressants because of their analgesic effects however, the nature of neuropathic pain is its chronicity and as such often becomes recalcitrant to these pharmacological strategies. Interestingly, adjuvant therapies for these disorders including chemotherapy and radiation therapy can also lead to chronic neuropathy. For this reason, several diseases manifest with neuropathy including SCI, stroke, multiple sclerosis, diabetes, infectious related, nutrient deficient, immune related, and oncological. 8, 24 Unlike nociceptive pain (tissue-injury induced), neuropathic pain is specific to injury of either the central or peripheral nervous system and can be a combination of both. Diabetic and nondiabetic patients were surveyed for sick days from work due to neuropathic pain approximately two-thirds of these patients were found to consistently be taking days from work, and only one-fifth of those were satisfied with their current therapy. C hronic neuropathic pain is estimated to be on the rise, particularly with the expected increase in patients with diabetes within the US.

Peripheral neuropathy stem cell treatment